{"id":362,"date":"2023-05-22T11:17:32","date_gmt":"2023-05-22T02:17:32","guid":{"rendered":"https:\/\/smu-og.com\/?page_id=362"},"modified":"2026-04-08T10:51:50","modified_gmt":"2026-04-08T01:51:50","slug":"%e7%94%9f%e6%ae%96%e5%86%85%e5%88%86%e6%b3%8c%e7%a0%94%e7%a9%b6%e5%ae%a4","status":"publish","type":"page","link":"https:\/\/smu-og.com\/?page_id=362","title":{"rendered":"\u751f\u6b96\u5185\u5206\u6ccc\u30fb\u5468\u7523\u671f\u7814\u7a76\u5ba4"},"content":{"rendered":"<h4><strong>\u6982\u8981<\/strong><\/h4>\n<p>\u79c1\u305f\u3061\u306e\u7814\u7a76\u5ba4\u3067\u306f\u3001\u5927\u304d\u304f\u5206\u3051\u3066\u2460\u5b50\u5bae\u5185\u819c\u8131\u843d\u819c\u5316\u6a5f\u69cb\u306e\u89e3\u6790\u2461\u5b50\u5bae\u5185\u819c\u75c7\u306e\u767a\u75c7\u30e1\u30ab\u30cb\u30ba\u30e0\u3068\u65b0\u898f\u6cbb\u7642\u85ac\u306e\u958b\u767a\u2462\u30da\u30eb\u30aa\u30ad\u30b7\u30bd\u30fc\u30e0\u3068\u7cbe\u5b50\u6a5f\u80fd\u2463\u7d68\u6bdb\u7d30\u80de\u306e\u6a5f\u80fd\u89e3\u6790\u3068\u5468\u7523\u671f\u75be\u60a3\u3068\u306e\u95a2\u9023\u306a\u3069\u306e\u30d7\u30ed\u30b8\u30a7\u30af\u30c8\u306e\u5b9f\u7e3e\u304c\u3042\u308a\u307e\u3059\u3002\u307e\u305f\u3001\u672c\u5b66\u306e\u751f\u7406\u5b66\u6559\u5ba4\u3001\u85ac\u7406\u5b66\u6559\u5ba4\u3001\u53e3\u8154\u5916\u79d1\u6559\u5ba4\u3001\u4e2d\u592e\u7814\u7a76\u65bd\u8a2d\u3001\u4ed6\u5927\u5b66\u3068\u3057\u3066\u6771\u4eac\u85ac\u79d1\u5927\u5b66\u85ac\u7406\u5b66\u6559\u5ba4\u3084\u6d77\u5916\u3067\u306f\u30a4\u30ae\u30ea\u30b9\u306e<span>Warwick<\/span>\u5927\u5b66\u306a\u3069\u3068\u5171\u540c\u7814\u7a76\u3092\u884c\u3063\u3066\u304a\u308a\u307e\u3059\u3002\u3053\u308c\u307e\u3067\u306b\u7559\u5b66\u751f\u3082\u7a4d\u6975\u7684\u306b\u53d7\u3051\u5165\u308c\u3066\u304a\u308a\u3001\u30bf\u30a4\u304b\u3089<span>2<\/span>\u540d\u3001\u30d0\u30f3\u30b0\u30e9\u30c7\u30a3\u30b7\u30e5\u304b\u3089<span>1<\/span>\u540d\u306e\u7559\u5b66\u751f\u3092\u53d7\u3051\u5165\u308c\u3066\u304a\u308a\u307e\u3059\u3002<\/p>\n<h5>1. \u5b50\u5bae\u5185\u819c\u306e\u8131\u843d\u819c\u5316\u6a5f\u69cb\u306e\u89e3\u6790<\/h5>\n<p>\u8131\u843d\u819c\uff08<span>deciduas<\/span>\uff09\u306f\u598a\u5a20\u306e\u6210\u7acb\u306b\u4f34\u3044\u5909\u5316\u3057\u3001\u598a\u5a20\u306e\u7d42\u7d50\u306b\u4f34\u3044\u80ce\u76e4\u3068\u3068\u3082\u306b\u5265\u8131\u3059\u308b\u5b50\u5bae\u5185\u819c\u7d44\u7e54\u306e\u4e00\u90e8\u3068\u5b9a\u7fa9\u3055\u308c\u307e\u3059\u3002\u307e\u305f\u5b50\u5bae\u5185\u819c\u9593\u8cea\u7d30\u80de\u304c\u598a\u5375\u306e\u7740\u5e8a\u306b\u4f34\u3044\u5f62\u614b\u5b66\u7684\u304a\u3088\u3073\u6a5f\u80fd\u7684\u306b\u5206\u5316\u3092\u3059\u308b\u904e\u7a0b\u3092\u8131\u843d\u819c\u5316\uff08<span>decidualization<\/span>\uff09\u3068\u3044\u3044\u3001\u3053\u306e\u5206\u5316\u904e\u7a0b\u306f\u7d68\u6bdb\u7d30\u80de\u306e\u6d78\u6f64\u3001\u80ce\u76e4\u5f62\u6210\u306b\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u3066\u3044\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u8131\u843d\u819c\u5316\u306e\u5f62\u614b\u5b66\u7684\u7279\u5fb4\u3068\u3057\u3066\u306f\u5927\u578b\u3067\u6577\u77f3\u72b6\u306e\u914d\u5217\u3092\u793a\u3059\u4e0a\u76ae\u7d30\u80de\u69d8\u5f62\u614b\u304c\u6319\u3052\u3089\u308c\u3001\u6a5f\u80fd\u7684\u7279\u5fb4\u3068\u3057\u3066\u306f\u30b9\u30c6\u30ed\u30a4\u30c9\u30db\u30eb\u30e2\u30f3\u53d7\u5bb9\u4f53\u306e\u767a\u73fe\u3001\u30b9\u30c6\u30ed\u30a4\u30c9\u4ee3\u8b1d\u3001\u7d30\u80de\u9aa8\u683c\u306e\u518d\u69cb\u6210\u3001\u6210\u9577\u56e0\u5b50\u3001\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u3001\u305d\u306e\u53d7\u5bb9\u4f53\u306e\u767a\u73fe\u306e\u5909\u5316\u7b49\u304c\u6319\u3052\u3089\u308c\u307e\u3059\u3002\u30d2\u30c8\u306a\u3069\u6708\u7d4c\u306e\u3042\u308b\u52d5\u7269\u7a2e\u306b\u304a\u3044\u3066\u3001\u8131\u843d\u819c\u5316\u5909\u5316\u306f\u80da\u306e\u5b58\u5728\u306e\u6709\u7121\u306b\u95a2\u4fc2\u306a\u304f\u5206\u6ccc\u671f\u4e2d\u671f\u4ee5\u964d\u306b\u306f\u5b50\u5bae\u5185\u819c\u306e\u6a5f\u80fd\u5c64\u306b\u304a\u3044\u3066\u89b3\u5bdf\u3055\u308c\u307e\u3059\u3002\u8131\u843d\u819c\u5316\u306e\u969c\u5bb3\u306f\u3001\u4e0d\u598a\u3001\u53cd\u5fa9\u6d41\u7523\u3001\u598a\u5a20\u9ad8\u8840\u5727\u75c7\u5019\u7fa4\u3001\u80ce\u5150\u767a\u80b2\u9045\u5ef6\u306a\u3069\u306e\u598a\u5a20\u306b\u95a2\u9023\u3057\u305f\u75be\u60a3\u3060\u3051\u3067\u306f\u306a\u304f\u3001\u5b50\u5bae\u5185\u819c\u75c7\u3001\u5b50\u5bae\u5185\u819c\u764c\u306e\u767a\u75c7\u306b\u95a2\u9023\u3057\u3059\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u304a\u308a\u307e\u3059\uff08\u56f3\uff11\uff09\u3002<br \/>\n<span>\u3053\u308c\u307e\u3067\u306e\u79c1\u305f\u3061\u306e\u7814\u7a76\u3067\u3001<\/span><span lang=\"EN-US\">Forkhead<\/span>\u8ee2<wbr \/>\u5199\u56e0\u5b50\u306e\u3072\u3068\u3064\u3067\u3042\u308b<span lang=\"EN-US\">FOXO1<\/span>\u304c\u6a19\u7684\u907a\u4f1d\u5b50<span>\u3067\u3042\u308b<\/span><span lang=\"EN-US\">Bim<\/span><span>\u3084<\/span><span lang=\"EN-US\">SO<wbr \/>D2\u306e<\/span><span>\u767a\u73fe\u3092\u8a98\u5c0e\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u6708\u7d4c\u306e\u767a\u6765\u3001<\/span>\u8131\u843d\u819c\u5316\u7d30\u80de\u306e\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u62b5\u6297\u6027\u306e\u7372\u5f97\u7b49\u306b\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u660e\u304b\u3068\u3057\u3066\u3044\u307e\u3059\u3002<br \/>\n\u307e\u305f\u8131\u843d\u819c\u5316\u904e\u7a0b\u3067\u767a\u73fe\u304c\u5909\u52d5\u3059\u308b\uff16\u3064\u306e<span>microRNA<\/span>\uff08<span>18<\/span>\u301c<span>25<\/span>\u5869\u57fa\u9577\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u30b3\u30fc\u30c9\u3057\u306a\u3044\u30ce\u30f3\u30b3\u30fc\u30c7\u30a3\u30f3\u30b0<span>RNA<\/span>\u3002\u305d\u306e\u4ed6\u306e\u30b3\u30fc\u30c7\u30a3\u30f3\u30b0\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u3092\u5236\u5fa1\u3059\u308b\u6a5f\u80fd\u3092\u6301\u3064\uff09\u3092\u540c\u5b9a\u3057\u307e\u3057\u305f\uff08\u56f3\uff12\uff09\u3002\u305d\u306e\u4e2d\u306e<span>miR-542-3p<\/span>\u306f\u8131\u843d\u819c\u5316\u30de\u30fc\u30ab\u30fc\u3068\u3057\u3066\u3088\u304f\u77e5\u3089\u308c\u3066\u3044\u308b<span>IGFBP1<\/span>\u306e\u767a\u73fe\u3092\u5236\u5fa1\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u8131\u843d\u819c\u5316\u904e\u7a0b\u3092\u5f62\u614b\u7684\u306b\u3082\u6a5f\u80fd\u7684\u306b\u3082\u5236\u5fa1\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u660e\u3089\u304b\u3068\u3057\u3066\u304a\u308a\u307e\u3059\u3002<br \/>\n\u305d\u306e\u4e2d\u306e<span>miR-542-3p<\/span>\u306f\u8131\u843d\u819c\u5316\u30de\u30fc\u30ab\u30fc\u3068\u3057\u3066\u3088\u304f\u77e5\u3089\u308c\u3066\u3044\u308b<span>IGFBP1<\/span>\u306e\u767a\u73fe\u3092\u5236\u5fa1\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u8131\u843d\u819c\u5316\u904e\u7a0b\u3092\u5f62\u614b\u7684\u306b\u3082\u6a5f\u80fd\u7684\u306b\u3082\u5236\u5fa1\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u660e\u304b\u3068\u3057\u3066\u304a\u308a\u307e\u3059\u3002<\/p>\n<table style=\"width: 74.0241%; border-collapse: collapse; border-style: hidden;\" class=\" aligncenter\">\n<tbody>\n<tr>\n<td style=\"width: 38.3759%; text-align: center; vertical-align: middle;\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/smu-og.com\/1_web\/wp-content\/uploads\/2023\/05\/image1-300x179.png\" alt=\"\" width=\"300\" height=\"179\" class=\"size-medium wp-image-354 aligncenter\" srcset=\"https:\/\/smu-og.com\/1_web\/wp-content\/uploads\/2023\/05\/image1-300x179.png 300w, https:\/\/smu-og.com\/1_web\/wp-content\/uploads\/2023\/05\/image1.png 707w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/td>\n<td style=\"width: 35.6501%; border-style: hidden; text-align: center; vertical-align: middle;\">\n<p><div id=\"attachment_355\" style=\"width: 227px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-355\" src=\"https:\/\/smu-og.com\/1_web\/wp-content\/uploads\/2023\/05\/image2-217x300.jpg\" alt=\"\" width=\"217\" height=\"300\" class=\"size-medium wp-image-355 aligncenter\" srcset=\"https:\/\/smu-og.com\/1_web\/wp-content\/uploads\/2023\/05\/image2-217x300.jpg 217w, https:\/\/smu-og.com\/1_web\/wp-content\/uploads\/2023\/05\/image2.jpg 697w\" sizes=\"auto, (max-width: 217px) 100vw, 217px\" \/><p id=\"caption-attachment-355\" class=\"wp-caption-text\">\u56f32<\/p><\/div><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h5>2. \u5b50\u5bae\u5185\u819c\u75c7\u306e\u767a\u75c7\u30e1\u30ab\u30cb\u30ba\u30e0\u3068\u65b0\u898f\u6cbb\u7642\u85ac\u306e\u958b\u767a<\/h5>\n<p>\u5b50\u5bae\u5185\u819c\u75c7\u306f\u751f\u6b96\u5e74\u9f62\u5973\u6027\u306e\u7d04\uff11\u5272\u306b\u767a\u75c7\u3057\u3001\u6708\u7d4c\u56f0\u96e3\u75c7\u30fb\u4e0d\u598a\u75c7\u30fb\u764c\u5316\u306b\u3088\u308a\u5973\u6027\u306e<span>QOL<\/span>\u3092\u8457\u3057\u304f\u4f4e\u4e0b\u3055\u305b\u308b\u75be\u60a3\u3067\u3059\u3002\u6708\u7d4c\u6642\u306b\u5375\u7ba1\u3092\u9006\u6d41\u3057\u305f\u5b50\u5bae\u5185\u819c\u304c\u9aa8\u76e4\u8179\u819c\u306b\u751f\u7740\u3059\u308b\u3053\u3068\u304c\u767a\u75c7\u306e\u521d\u671f\u6bb5\u968e\u3068\u3059\u308b<span>\u201c<\/span>\u9006\u6d41\u6708\u7d4c\u8aac<span>\u201d<\/span>\u304c\u5b50\u5bae\u5185\u819c\u75c7\u306e\u6700\u6709\u529b\u767a\u75c7\u4eee\u8aac\u3067\u3059\u304c\u9006\u6d41\u6708\u7d4c\u8840\u306f<span>9<\/span>\u5272\u306e\u751f\u6b96\u5e74\u9f62\u5973\u6027\u306b\u8a8d\u3081\u308b\u3042\u308a\u3075\u308c\u305f\u73fe\u8c61\u3067\u3059\u3002\u5065\u5e38\u5973\u6027\u306b\u304a\u3044\u3066\u306f\u9006\u6d41\u3057\u305f\u5b50\u5bae\u5185\u819c\u306f\u9aa8\u76e4\u5185\u306e\u514d\u75ab\u7d30\u80de\u306b\u3088\u3063\u3066\u8caa\u98df\u9664\u53bb\u3055\u308c\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u304c\u3001\u5b50\u5bae\u5185\u819c\u75c7\u60a3\u8005\u3067\u306f\u3053\u306e\u514d\u75ab\u6a5f\u69cb\u304c\u6a5f\u80fd\u305b\u305a\u9aa8\u76e4\u8179\u819c\u306b\u751f\u7740\u3057\u5897\u6b96\u3059\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002<br \/>\n\u5b50\u5bae\u5185\u819c\u75c7\u3067\u306f\u8179\u8154\u5185\u514d\u75ab\u53ca\u3073\u5b50\u5bae\u5185\u819c\u306e\u907a\u4f1d\u5b50\u767a\u73fe\u7570\u5e38\u304c\u591a\u6570\u5831\u544a\u3055\u308c\u3066\u304a\u308a\u3001\u514d\u75ab\u6a5f\u69cb\u306e\u56de\u907f\u306b\u95a2\u4e0e\u3057\u3066\u3044\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u307e\u3067\u6211\u3005\u306e\u7814\u7a76\u3067\u306f\u3001\u5b50\u5bae\u5185\u819c\u75c7\u75c5\u5de3\u306b\u304a\u3051\u308b\u597d\u4e2d\u7403\u306e\u96c6\u7a4d\u30e1\u30ab\u30cb\u30ba\u30e0\u3084\u3001<span>CD4<\/span>\u967d\u6027<span>T<\/span>\u7d30\u80de\u306e\u30d0\u30e9\u30f3\u30b9\u304c\u504f\u3063\u3066\u3044\u308b\u3053\u3068\u3001\u597d\u4e2d\u7403\u304c\u5b50\u5bae\u5185\u819c\u75c7\u75c5\u5de3\u5f62\u6210\u306b\u91cd\u8981\u306a\u50cd\u304d\u3092\u3059\u308b\u3053\u3068\u7b49\u3092\u5831\u544a\u3057\u3066\u304d\u307e\u3057\u305f\u3002\u6700\u8fd1\u3067\u306f\u3001\u4e0d\u598a\u75c7\u306e\u73fe\u5834\u3067\u6ce8\u76ee\u3055\u308c\u3066\u3044\u308b\u6162\u6027\u5b50\u5bae\u5185\u819c\u708e\uff08<span>CE<\/span>\uff09\u304c\u5b50\u5bae\u5185\u819c\u75c7\u60a3\u8005\u306b\u304a\u3044\u3066\u591a\u304f\u7f79\u60a3\u3057\u3066\u3044\u308b\u3068\u3044\u3046\u5831\u544a\u304c\u591a\u6570\u3042\u308a\u3001<span>CE<\/span>\u304c\u5b50\u5bae\u5185\u819c\u75c7\u767a\u75c7\u306b\u95a2\u4e0e\u3059\u308b\u3068\u3044\u3046\u4eee\u8aac\u306e\u4e0b\u3001\u7814\u7a76\u306b\u53d6\u308a\u7d44\u3093\u3067\u304a\u308a\u307e\u3059\u3002<br \/>\n\u73fe\u5728\u7528\u3044\u3089\u308c\u3066\u3044\u308b\u5b50\u5bae\u5185\u819c\u75c7\u6cbb\u7642\u306f\u5973\u6027\u30db\u30eb\u30e2\u30f3\u306e\u5206\u6ccc\u306b\u95a2\u308f\u308b\u88fd\u5264\u304c\u4e3b\u8ef8\u3067\u3059\u3002\u30db\u30eb\u30e2\u30f3\u88fd\u5264\u306f\u526f\u4f5c\u7528\u3082\u591a\u304f\u3001\u6319\u5150\u3092\u5e0c\u671b\u3059\u308b\u60a3\u8005\u306b\u7528\u3044\u3089\u308c\u306a\u3044\u3068\u3044\u3046\u30c7\u30e1\u30ea\u30c3\u30c8\u304c\u3042\u308a\u307e\u3059\u3002\u30db\u30eb\u30e2\u30f3\u306b\u4f9d\u5b58\u3057\u306a\u3044\u65b0\u305f\u306a\u6cbb\u7642\u6a19\u7684\u3092\u63a2\u3057\u3001\u7814\u7a76\u3092\u9032\u3081\u3066\u53c2\u308a\u307e\u3059\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/smu-og.com\/1_web\/wp-content\/uploads\/2023\/05\/image3-1-300x225.png\" alt=\"\" width=\"300\" height=\"225\" class=\"alignnone size-medium wp-image-408\" srcset=\"https:\/\/smu-og.com\/1_web\/wp-content\/uploads\/2023\/05\/image3-1-300x225.png 300w, https:\/\/smu-og.com\/1_web\/wp-content\/uploads\/2023\/05\/image3-1-1024x768.png 1024w, https:\/\/smu-og.com\/1_web\/wp-content\/uploads\/2023\/05\/image3-1-768x576.png 768w, https:\/\/smu-og.com\/1_web\/wp-content\/uploads\/2023\/05\/image3-1-1536x1152.png 1536w, https:\/\/smu-og.com\/1_web\/wp-content\/uploads\/2023\/05\/image3-1-2048x1536.png 2048w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/p>\n<h5>3. \u30da\u30eb\u30aa\u30ad\u30b7\u30bd\u30fc\u30e0\u3068\u7cbe\u5b50\u6a5f\u80fd<\/h5>\n<p>\u73fe\u5728\u306e\u4e0d\u598a\u6cbb\u7642\u306f\u3001\u4f53\u5916\u53d7\u7cbe\u30fb\u80da\u79fb\u690d<span>(IVF-ET)<\/span>\u30fb\u9855\u5fae\u6388\u7cbe<span>(ICSI)<\/span>\u3068\u3044\u3063\u305f\u751f\u6b96\u88dc\u52a9\u533b\u7642\u304c\u4e2d\u5fc3\u306b\u884c\u308f\u308c\u3066\u3044\u307e\u3059\u304c\u3001\u9855\u5fae\u6388\u7cbe\u306b\u304a\u3044\u3066\u306f\u3001\u5f62\u614b\u7684\u306b\u826f\u597d\u3067\u904b\u52d5\u6027\u306e\u3042\u308b\u7cbe\u5b50\u3092\u9078\u5225\u3057\u3066\u5375\u5b50\u306b\u6ce8\u5165\u3057\u3066\u3082\u3001\u5fc5\u305a\u3057\u3082\u598a\u5a20\u304c\u6210\u7acb\u3059\u308b\u3068\u306f\u9650\u3089\u306a\u3044\u73fe\u72b6\u304c\u3042\u308a\u307e\u3059\u3001\u3053\u308c\u307e\u3067\u751f\u6b96\u88dc\u52a9\u533b\u7642\u306b\u304a\u3044\u3066\u3001\u7cbe\u5b50\u3001\u5375\u5b50\u306e\u67d3\u8272\u4f53\u7570\u5e38\u3084\u3001\u53d7\u7cbe\u5375\u306e\u67d3\u8272\u4f53\u7570\u6570\u6027\u304c\u4e0d\u6210\u529f\u306e\u6700\u3082\u591a\u3044\u539f\u56e0\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3057\u305f\u3002\u3057\u304b\u3057\u3001\u6b63\u6570\u6027\u306e\u53d7\u7cbe\u5375\u3092\u5b50\u5bae\u5185\u306b\u79fb\u690d\u3057\u3066\u3082\u7d04<span>40<\/span>\uff05\u306f\u7740\u5e8a\u304c\u6210\u7acb\u3057\u306a\u3044\u3068\u5831\u544a\u3055\u308c\u3066\u304a\u308a\uff08<span>Harton GL, et al. 2013<\/span>\uff09\u3001\u53d7\u7cbe\u5375\u306e\u7570\u6570\u6027\u4ee5\u5916\u304c\u539f\u56e0\u3068\u8003\u3048\u3089\u308c\u308b\u598a\u5a20\u4e0d\u6210\u7acb\u304c\u591a\u304f\u5b58\u5728\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u304d\u307e\u3057\u305f\u3002\u3053\u306e\u3053\u3068\u304b\u3089\u3001\u4e0d\u598a\u6cbb\u7642\u306e\u6210\u7e3e\u5411\u4e0a\u306e\u305f\u3081\u306b\u306f\u3001\u65b0\u898f\u6cbb\u7642\u6cd5\u306e\u958b\u767a\u304c\u6c42\u3081\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u79c1\u305f\u3061\u306f\u3001\u7537\u6027\u4e0d\u598a\u75c7\u306e\u3046\u3061\u3001\u30da\u30eb\u30aa\u30ad\u30b7\u30bd\u30fc\u30e0\u306e\u8102\u8cea\u4ee3\u8b1d\u6a5f\u80fd\u4f4e\u4e0b\u306b\u7740\u76ee\u3057\u3066\u7814\u7a76\u3092\u9032\u3081\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u307e\u3067\u306b\u3001\u30da\u30eb\u30aa\u30ad\u30b7\u30bd\u30fc\u30e0\u306e\u8102\u8cea\u4ee3\u8b1d\u6a5f\u80fd\u306e\u4f4e\u4e0b\u3092\u5448\u3059\u308b\u30de\u30a6\u30b9\u304c\u96c4\u6027\u4e0d\u598a\u3092\u5448\u3059\u308b\u3053\u3068\u3092\u660e\u3089\u304b\u306b\u3057\u307e\u3057\u305f\u3002\u73fe\u5728\u3001\u3053\u306e\u30de\u30a6\u30b9\u306e\u7cbe\u5b50\u5f62\u614b\u306e\u6539\u5584\u306b\u52b9\u679c\u304c\u3042\u308b\u7269\u8cea\u3092\u767a\u898b\u3059\u308b\u306a\u3069\u306e\u6210\u679c\u3092\u4e0a\u3052\u3066\u3044\u307e\u3059\u3002\u3055\u3089\u306b\u3001\u7cbe\u5b50\u306e\u904b\u52d5\u6027\u3084\u598a\u5b55\u6027\u306e\u5411\u4e0a\u306b\u5f79\u7acb\u3064\u56e0\u5b50\u306b\u3064\u3044\u3066\u7814\u7a76\u3092\u9032\u3081\u3066\u3044\u307e\u3059\u3002<\/p>\n<h5>4. \u7d68\u6bdb\u7d30\u80de\u306e\u6a5f\u80fd\u3068\u5468\u7523\u671f\u75be\u60a3\u3068\u306e\u95a2\u9023<\/h5>\n<p>\u30d2\u30c8\u80ce\u76e4\u7d68\u6bdb\u7d30\u80de\u4e2d\u306e\u591a\u304f\u306e\u30de\u30a4\u30af\u30ed<span>RNA<\/span>\u767a\u73fe\u304c\u3001\u4f4e\u9178\u7d20\u74b0\u5883\u306b\u304a\u3044\u3066\u5909\u5316\u3059\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u304c\u3001\u305d\u306e\u3088\u3046\u306a\u74b0\u5883\u3067\u3001\u7d68\u6bdb\u7d30\u80de\u306e\u6d78\u6f64\u80fd\u304c\u30de\u30a4\u30af\u30ed<span>RNA<\/span>\u306b\u3088\u308a\u3069\u3046\u3044\u3063\u305f\u8abf\u7bc0\u3092\u53d7\u3051\u308b\u306e\u304b\u306f\u672a\u89e3\u660e\u3067\u3042\u308a\u307e\u3057\u305f\u3002\u5f53\u7814\u7a76\u5ba4\u3067\u306f\u3001\u4f4e\u9178\u7d20\u74b0\u5883\u3067\u3001\u7d68\u6bdb\u7d30\u80de\u306e\u6d78\u6f64\u80fd\u3092\u8abf\u7bc0\u3059\u308b\u30de\u30a4\u30af\u30ed<span>RNA<\/span>\u3068\u305d\u306e\u6a19\u7684\u907a\u4f1d\u5b50\u3092\u660e\u3089\u304b\u306b\u3057\u3001\u305d\u306e\u6a5f\u80fd\u3092\u89e3\u6790\u3057\u3066\u307e\u3044\u308a\u307e\u3057\u305f\u3002\u5177\u4f53\u7684\u306b\u306f\u3001\u30d2\u30c8\u7d68\u6bdb\u5916\u7d68\u6bdb\u7d30\u80de\u682a\u3067\u3042\u308b<span>HTR-8\/SVneo<\/span>\u3092\u4f4e\u9178\u7d20\u6fc3\u5ea6\u6761\u4ef6\u306b\u3059\u308b\u3068\u3001\u7d30\u80de\u6d78\u6f64\u80fd\u306f\u4f4e\u4e0b\u3057\u3001\u30de\u30a4\u30af\u30ed<span>RNA-135b<\/span>\u306e\u767a\u73fe\u304c\u5897\u52a0\u3059\u308b\u3053\u3068\u3092\u660e\u3089\u304b\u306b\u3057\u307e\u3057\u305f\u3002\u307e\u305f\u3001\u305d\u306e\u6a19\u7684\u907a\u4f1d\u5b50\u306e\u3046\u3061\u30b1\u30e2\u30ab\u30a4\u30f3\u306e\u4e00\u7a2e\u3067\u3042\u308b<span>CXCL12<\/span>\u306e\u767a\u73fe\u3092\u3001\u30de\u30a4\u30af\u30ed<span>RNA-135b<\/span>\u304c\u76f4\u63a5\u6291\u5236\u3059\u308b\u3068\u3044\u3046\u6a5f\u69cb\u3092\u4ecb\u3057\u3066\u3001\u7d30\u80de\u6d78\u6f64\u80fd\u304c\u8abf\u7bc0\u3055\u308c\u308b\u3068\u3044\u3046\u3053\u3068\u3082\u767a\u898b\u3044\u305f\u3057\u307e\u3057\u305f\u3002\u3053\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u306f\u3001\u80ce\u76e4\u5f62\u6210\u306e\u904e\u7a0b\u306b\u95a2\u308f\u3063\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u3001\u672c\u7814\u7a76\u306e\u6210\u679c\u306f\u3001\u80ce\u76e4\u5f62\u6210\u4e0d\u5168\u304c\u75c5\u614b\u306e\u6839\u5e95\u306b\u3042\u308b\u598a\u5a20\u9ad8\u8840\u5727\u75c7\u5019\u7fa4\u3084\u80ce\u5150\u767a\u80b2\u4e0d\u5168\u3068\u3044\u3063\u305f\u75be\u60a3\u306e\u75c5\u614b\u89e3\u660e\u306b\u3080\u3051\u305f\u4e00\u6b69\u3068\u8003\u3048\u3066\u304a\u308a\u307e\u3059\u3002<br \/>\n\u307e\u305f\u3001\u524d\u8ff0\u306e\u30d7\u30ed\u30b8\u30a7\u30af\u30c8\u3067\u306f\u3001\u4f4e\u9178\u7d20\u6761\u4ef6\u3067\u7279\u306b\u30de\u30a4\u30af\u30ed<span>RNA-210<\/span>\u306e\u767a\u73fe\u304c\u6700\u3082\u5897\u52a0\u3057\u3001<span>in silico<\/span>\u306e\u89e3\u6790\u3067\u9244\u4ee3\u8b1d\u306b\u95a2\u9023\u3059\u308b\u91cd\u8981\u306a\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u304c\u5927\u304d\u304f\u4f4e\u4e0b\u3059\u308b\u3053\u3068\u3082\u898b\u51fa\u3057\u307e\u3057\u305f\u3002\u4f4e\u9178\u7d20\u6761\u4ef6\u4e0b\u3067\u5909\u52d5\u3059\u308b\u9244\u306f\u3001\u7d30\u80de\u5185\u3067\u306e\u30a8\u30cd\u30eb\u30ae\u30fc\u7523\u751f\u306b\u5fc5\u9808\u3067\u3042\u308b\u4ed6\u3001\u69d8\u3005\u306a\u9175\u7d20\u306e\u6d3b\u6027\u4e2d\u5fc3\u3068\u3057\u3066\u3082\u50cd\u304d\u3001\u7d30\u80de\u6a5f\u80fd\u7dad\u6301\u306b\u3068\u3066\u3082\u91cd\u8981\u306a\u5fae\u91cf\u91d1\u5c5e\u3067\u3042\u308b\u3068\u3068\u3082\u306b\u3001\u598a\u5a20\u9ad8\u8840\u5727\u814e\u75c7\u3084\u80ce\u5150\u767a\u80b2\u4e0d\u5168\u306e\u80ce\u76e4\u3067\u306f\u3001\u9244\u4ee3\u8b1d\u304c\u5927\u304d\u304f\u5909\u5316\u3059\u308b\u3053\u3068\u304c\u3053\u308c\u307e\u3067\u306b\u660e\u3089\u304b\u306b\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3057\u305f\u304c\u3063\u3066\u3001\u3053\u306e\u3088\u3046\u306a\u75be\u60a3\u306e\u75c5\u614b\u5f62\u6210\u306b\u9244\u4ee3\u8b1d\u304c\u95a2\u4e0e\u3059\u308b\u53ef\u80fd\u6027\u3092\u8003\u3048\u3001\u305d\u306e\u751f\u7406\u5b66\u7684\u3001\u75c5\u614b\u5b66\u7684\u5f79\u5272\u3092\u89e3\u660e\u3059\u3079\u304f\u7814\u7a76\u3092\u9032\u3081\u3066\u304a\u308a\u307e\u3059\u3002<\/p>\n<h4><strong>\u6d3b\u52d5\u98a8\u666f<\/strong><\/h4>\n<table style=\"border-collapse: collapse; width: 100%;\">\n<tbody>\n<tr>\n<td style=\"width: 33.3333%;\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/smu-og.com\/1_web\/wp-content\/uploads\/2023\/05\/image4-300x225.jpg\" alt=\"\" width=\"300\" height=\"225\" class=\"size-medium wp-image-369 aligncenter\" srcset=\"https:\/\/smu-og.com\/1_web\/wp-content\/uploads\/2023\/05\/image4-300x225.jpg 300w, https:\/\/smu-og.com\/1_web\/wp-content\/uploads\/2023\/05\/image4-768x576.jpg 768w, https:\/\/smu-og.com\/1_web\/wp-content\/uploads\/2023\/05\/image4.jpg 1024w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/td>\n<td style=\"width: 33.3333%;\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/smu-og.com\/1_web\/wp-content\/uploads\/2023\/05\/image5-300x225.jpg\" alt=\"\" width=\"300\" height=\"225\" class=\"size-medium wp-image-370 aligncenter\" srcset=\"https:\/\/smu-og.com\/1_web\/wp-content\/uploads\/2023\/05\/image5-300x225.jpg 300w, https:\/\/smu-og.com\/1_web\/wp-content\/uploads\/2023\/05\/image5-768x576.jpg 768w, https:\/\/smu-og.com\/1_web\/wp-content\/uploads\/2023\/05\/image5.jpg 1024w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/td>\n<td style=\"width: 33.3333%;\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/smu-og.com\/1_web\/wp-content\/uploads\/2023\/05\/image6-300x225.jpg\" alt=\"\" width=\"300\" height=\"225\" class=\"size-medium wp-image-371 aligncenter\" srcset=\"https:\/\/smu-og.com\/1_web\/wp-content\/uploads\/2023\/05\/image6-300x225.jpg 300w, https:\/\/smu-og.com\/1_web\/wp-content\/uploads\/2023\/05\/image6-768x576.jpg 768w, https:\/\/smu-og.com\/1_web\/wp-content\/uploads\/2023\/05\/image6.jpg 1024w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/td>\n<\/tr>\n<tr>\n<td style=\"width: 33.3333%;\"><span style=\"font-size: 10pt;\">2012\u5e74 \u65e5\u672c\u81e8\u5e8a\u5206\u5b50\u5f62\u614b\u5b66\u4f1a\u5b66\u8853\u5968\u52b1\u8cde\u3092\u53d7\u8cde\u3057\u3066\u53d7\u8cde\u8b1b\u6f14\u3059\u308b\u68b6\u539f\u5148\u751f<\/span><\/td>\n<td style=\"width: 33.3333%;\"><span style=\"font-size: 10pt;\">2014\u5e74 \u65e5\u672c\u751f\u6b96\u533b\u5b66\u4f1a\u306e\u7279\u5225\u8b1b\u6f14\u306e\u305f\u3081\u6765\u65e5\u3057\u305fJ Brosens\u6559\u6388\u3068\u98df\u4e8b\u4f1a\uff08\u7bb1\u6839\uff09<\/span><\/td>\n<td style=\"width: 33.3333%;\"><span style=\"font-size: 10pt;\">2018\u5e74 \u5b66\u5185\u7814\u7a76\u767a\u8868\u4f1a\u3067\u512a\u79c0\u8cde\u3092\u53d7\u8cde\u3057\u305f\u5cb8\u7f8e\u88d5\u5b50\u5148\u751f\uff08\u5f53\u6642\u533b\u5b66\u90e84\u5e74\u751f\uff09<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h4>\u7814\u7a76\u696d\u7e3e\uff08\u82f1\u6587\u306e\u307f\uff09<\/h4>\n<ul>\n<li><span>Kusama K, Ashihara M, Okita M, Yoshida K, Suzuki M, Suzuki K, Hosokawa R, Yoshie M, Kojima J, Mizuno Y, Ono M, Nishi H, Kajihara T, Tamura K. Role of Transcription Factor, LIM Homeobox 9 (LHX9) in Inflammatory Response by PGE2 and Thrombin in SERPINA1-Silencing Endometrial Stromal Cells. Mol Reprod Dev. 2025 Aug;92(8):e70046.<\/span><\/li>\n<li>\n<div>Yamaguchi T, Takamura M, Tochigi H, Mizuno Y, Mizuno Y, Sato T, Tamaru S, Kusama K, Tamura K, Kamei Y, Kajihara T. Loss of miR-424 and miR-503 promotes decidualization of human endometrial stromal cells by increasing SCARA5 expression.<span> <\/span>Med Mol Morphol. 2025 Mar 14. doi: 10.1007\/s00795-025-00431-5.<\/div>\n<\/li>\n<li>\n<div>Yamagata K, Mizuno Y, Mizuno Y, Tamaru S, Kajihara T. Androgens modulate endometrial function.<span> <\/span>Med Mol Morphol. 2025 Mar 10. doi:10.1007\/s00795-025-00430-<wbr \/>6.<\/div>\n<\/li>\n<li>\n<div>Mizuno Y, Tamaru S, Tochigi H, Sato T, Kishi M, Ohtake A, Ishihara O, Kajihara T. Decidualized Endometrial Stromal Cells Promote Mitochondrial Beta-Oxidation to Produce the Octanoic Acid Required for Implantation.<span> <\/span>\u00a0Biomolecules.2024 Aug 16;14(8):1014. doi: 10.3390\/biom14081014.<\/div>\n<\/li>\n<li><span>Takano N, Takamura M, Mizuno Y, Mizuno Y, Tamaru S, Nakamura K, Soma H, <\/span><span>Kajihara T. Genetic and histological analysis intraplacental choriocarcinoma: a <\/span><span>case report. Med Mol Morphol. 2024. doi: 10.1007<\/span><\/li>\n<li><span>Ito K, Go Y, Tatsumoto S, Usui C, Mizuno Y, Ikami E, Isozaki Y, Usui M, <\/span><span>Kajihara T, Yoda T, Inoue KI, Takada M, Sato T. Gene expression profiling of the <\/span><span>masticatory muscle tendons and Achilles tendons under tensile strain in the <\/span><span>Japanese macaque Macaca fuscata. PLoS One. 2023; 18(1): e0280649.<\/span><\/li>\n<li><span>Kusama K, Satoyoshi A, Azumi M, Yoshie M, Kojima J, Mizuno Y, Ono M, Nishi H, <\/span><span>Kajihara T, Tamura K. Toll-like receptor signaling pathway triggered by <\/span><span>inhibition of serpin A1 stimulates production of inflammatory cytokines by <\/span><span>endometrial stromal cells. Front Endocrinol (Lausanne). 2022; 13: 966455.<\/span><\/li>\n<li><span>Kusama K, Fukushima Y, Yoshida K, Azumi M, Yoshie M, Mizuno Y, Kajihara T, <\/span><span>Tamura K. PGE2 and Thrombin Induce Myofibroblast Transdifferentiation via <\/span><span>Activin A and CTGF in Endometrial Stromal Cells. Endocrinology. 2021;162(12): bqab207.<\/span><\/li>\n<li>Saito R, Kajihara T, Takamura M, Tochigi H, Sato T, Ishihara O. High stretch cycling inhibits the morphological and biological decidual process in human endometrial stromal cells. Reprod Med Biol. 19(4):378-384. 2020<\/li>\n<li>Tamaru S, Kajihara T, Mizuno Y, Mizuno Y, Tochigi H, Ishihara O. Endometrial microRNAs and their aberrant expression patterns. Med Mol Morphol. 53(3):131-140. 2020<\/li>\n<li>Tamaru S, Kajihara T, Mizuno Y, Takano N, Tochigi H, Sato T, Ishihara O. Heparin prevents oxidative stress-induced apoptosis in human decidualized endometrial stromal cells. Med Mol Morphol. 52(4):209-216. 2019<\/li>\n<li>Kimura M, Kajihara T, Mizuno Y, Sato T, Ishihara O. Loss of high-mobility group N5 contributes to the promotion of human endometrial stromal cell decidualization. Reprod Med Biol. 17(4):493-499. 2018<\/li>\n<li>Sultana S, Kajihara T, Mizuno Y, Sato T, Oguro T, Kimura M, Akita M, Ishihara O. Overexpression of microRNA-542-3p attenuates the differentiating capacity of endometriotic stromal cells. Reprod Med Biol. 16(2):170-178. 2017<\/li>\n<li>Tochigi H, Kajihara T, Mizuno Y, Mizuno Y, Tamaru S, Kamei Y, Okazaki Y, Brosens JJ, Ishihara O. Loss of miR-542-3p enhances IGFBP-1 expression in decidualizing human endometrial stromal cells. Sci Rep. 7:40001. 2017<\/li>\n<li>Wongwananuruk T, Sato T, Kajihara T, Matsumoto S, Akita M, Tamura K, Brosens JJ, Ishihara O. Endometrial androgen signaling and decidualization regulate trophoblast expansion and invasion in co-culture: A time-lapse study. Placenta. 47:56-62. 2016<\/li>\n<li>Tamaru S, Mizuno Y, Tochigi H, Kajihara T, Okazaki Y, Okagaki R, Kamei Y, Ishihara O, Itakura A. MicroRNA-135b suppresses extravillous trophoblast-derived HTR-8\/SVneo cell invasion by directly down regulating CXCL12 under\u00a0low oxygen conditions. Biochem Biophys Res Commun. 461(2):421-6. 2015<\/li>\n<li>Tamura K, Takashima H, Fumoto K, Kajihara T, Uchino S, Ishihara O, Yoshie M, Kusama K, Tachikawa E. Possible Role of \u03b11-Antitrypsin in Endometriosis-Like Grafts From a Mouse Model of Endometriosis. Reprod Sci. 22(9):1088-97. 2015<\/li>\n<li>Prechapanich J, Kajihara T, Fujita K, Sato K, Uchino S, Tanaka K, Matsumoto S, Akita M, Nagashima M, Brosens JJ, Ishihara O. Effect of a dienogest for an experimental three-dimensional endometrial culture model for endometriosis. Med Mol Morphol. 47(4):189-95. 2014<\/li>\n<li>Kajihara T, Tanaka K, Oguro T, Tochigi H, Prechapanich J, Uchino S, Itakura A, Su\u0107urovi\u0107 S, Murakami K, Brosens JJ, Ishihara O. Androgens modulate the morphological characteristics of human endometrial stromal cells decidualized in vitro. Reprod Sci. 21(3):372-80. 2014<\/li>\n<li>Mizuno Y, Ninomiya Y, Nakachi Y, Iseki M, Iwasa H, Akita M, Tsukui T, Shimozawa N, Ito C, Toshimori K, Nishimukai M, Hara H, Maeba R, Okazaki T, Alodaib AN, Al Amoudi M, Jacob M, Alkuraya FS, Horai Y, Watanabe M, Motegi H, Wakana S, Noda T, Kurochkin IV, Mizuno Y, Sch\u00f6nbach C, Okazaki Y. Tysnd1 deficiency in mice interferes with the peroxisomal localization of PTS2 enzymes, causing lipid metabolic abnormalities and male infertility. PLoS Genet. 9(2):e1003286. 2013<\/li>\n<li>Kajihara T, Brosens JJ, Ishihara O. The role of FOXO1 in the decidual transformation of the endometrium and early pregnancy. Med Mol Morphol. 46(2):61-8. 2013<\/li>\n<li>Kajihara T, Tochigi H, Prechapanich J, Uchino S, Itakura A, Brosens JJ, Ishihara O. Androgen signaling in decidualizing human endometrial stromal cells enhances resistance to oxidative stress. Fertil Steril. 97(1):185-91. 2012<\/li>\n<li>Kajihara T, Tochigi H, Uchino S, Itakura A, Brosens JJ, Ishihara O. Differential effects of urinary and recombinant chorionic gonadotropin on oxidative stress responses in decidualizing human endometrial stromal cells. Placenta. 32(8):592-7. 2011<\/li>\n<li>Kajihara T, Uchino S, Suzuki M, Itakura A, Brosens JJ, Ishihara O. Human chorionic gonadotropin confers resistance to oxidative stress-induced apoptosis in decidualizing human endometrial stromal cells. Fertil Steril. 95(4):1302-7. 2011<\/li>\n<li>Kajihara T, Uchino S, Suzuki M, Itakura A, Brosens JJ, Ishihara O. Increased ovarian follicle atresia in obese Zucker rats is associated with enhanced expression of the forkhead transcription factor FOXO1. Med Mol Morphol. 42(4):216-21. 2009<\/li>\n<li>Cloke B, Huhtinen K, Fusi L, Kajihara T, Yliheikkil\u00e4 M, Ho KK, Teklenburg G, Lavery S, Jones MC, Trew G, Kim JJ, Lam EW, Cartwright JE, Poutanen M, Brosens JJ. The androgen and progesterone receptors regulate distinct gene networks and cellular functions in decidualizing endometrium. Endocrinology. 149(9):4462-74. 2008<\/li>\n<li>Kajihara T, Okagaki R, Ishihara O. LPS-induced transient testicular dysfunction accompanied by apoptosis of testicular germ cells in mice. Med Mol Morphol. 39(4):203-8. 2006<\/li>\n<li>Kajihara T, Jones M, Fusi L, Takano M, Feroze-Zaidi F, Pirianov G, Mehmet H, Ishihara O, Higham JM, Lam EW, Brosens JJ. Differential expression of FOXO1 and FOXO3a confers resistance to oxidative cell death upon endometrial decidualization. Mol Endocrinol. 20(10):2444-55. 2006<\/li>\n<li>Labied S, Kajihara T, Madureira PA, Fusi L, Jones MC, Higham JM, Varshochi R, Francis JM, Zoumpoulidou G, Essafi A, Fernandez de Mattos S, Lam EW, Brosens JJ. Progestins regulate the expression and activity of the forkhead transcription factor FOXO1 in differentiating human endometrium. Mol Endocrinol. 20(1):35-44. 2006<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>\u6982\u8981 \u79c1\u305f\u3061\u306e\u7814\u7a76\u5ba4\u3067\u306f\u3001\u5927\u304d\u304f\u5206\u3051\u3066\u2460\u5b50\u5bae\u5185\u819c\u8131\u843d\u819c\u5316\u6a5f\u69cb\u306e\u89e3\u6790\u2461\u5b50\u5bae\u5185\u819c\u75c7\u306e\u767a\u75c7\u30e1\u30ab\u30cb\u30ba\u30e0\u3068\u65b0\u898f\u6cbb\u7642\u85ac\u306e\u958b\u767a\u2462\u30da\u30eb\u30aa\u30ad\u30b7\u30bd\u30fc\u30e0\u3068\u7cbe\u5b50\u6a5f\u80fd\u2463\u7d68\u6bdb\u7d30\u80de\u306e\u6a5f\u80fd\u89e3\u6790\u3068\u5468\u7523\u671f\u75be\u60a3\u3068\u306e\u95a2\u9023\u306a\u3069\u306e\u30d7\u30ed\u30b8\u30a7\u30af\u30c8\u306e\u5b9f\u7e3e\u304c\u3042\u308a\u307e\u3059\u3002\u307e\u305f [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":11,"menu_order":31,"comment_status":"closed","ping_status":"closed","template":"tpl_child.php","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-362","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/smu-og.com\/index.php?rest_route=\/wp\/v2\/pages\/362","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/smu-og.com\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/smu-og.com\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/smu-og.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/smu-og.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=362"}],"version-history":[{"count":25,"href":"https:\/\/smu-og.com\/index.php?rest_route=\/wp\/v2\/pages\/362\/revisions"}],"predecessor-version":[{"id":534,"href":"https:\/\/smu-og.com\/index.php?rest_route=\/wp\/v2\/pages\/362\/revisions\/534"}],"up":[{"embeddable":true,"href":"https:\/\/smu-og.com\/index.php?rest_route=\/wp\/v2\/pages\/11"}],"wp:attachment":[{"href":"https:\/\/smu-og.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=362"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}